Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 18/20 | 0.49 |
| ▸ | MMP12 | P39900 | 4/20 | 0.49 |
| ▸ | MMP14 | P50281 | 11/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL943704 | 0.89 | MMP13 (0.54) | MMP13MMP12MMP14FPR2PROKR1 | |
| SCHEMBL941666 | 0.87 | MMP13 (0.55) | MMP13MMP12MMP14FPR2PROKR1 | |
| SCHEMBL942210 | 0.86 | MMP13 (0.49) | MMP13MMP12MMP14FPR2PROKR1 | |
| SCHEMBL940657 | 0.86 | MMP13 (0.50) | MMP13MMP12MMP14FPR2PROKR1 | |
| SCHEMBL940856 | 0.84 | MMP13 (0.53) | MMP13MMP12MMP14FPR2PROKR1 | |
| SCHEMBL942265 | 0.84 | MMP13 (0.49) | MMP13MMP12MMP14FPR2PROKR1 | |
| SCHEMBL941012 | 0.84 | MMP13 (0.49) | MMP13MMP12MMP14FPR2PROKR1 | |
| SCHEMBL941706 | 0.84 | MMP13 (0.47) | MMP13MMP12MMP14FPR2PROKR1 | |
| SCHEMBL940710 | 0.84 | MMP13 (0.49) | MMP13MMP12MMP14FPR2PROKR1 | |
| SCHEMBL943814 | 0.83 | MMP13 (0.50) | MMP13MMP12MMP14FPR2PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110003853-A1 | Metalloproteinase Inhibitors | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | US | disclosed |
| US-7625934-B2 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2009-12-01 | — | — | US | disclosed |
| US-7427631-B2 | especially as inhibitors of MMP12 | ASTRAZENECA AB (SE) | 2008-09-23 | — | — | US | disclosed |
| US-20080171882-A1 | Metalloproteinase Inhibitors | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | US | disclosed |
| EP-1370556-B1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-07-19 | — | — | EP | disclosed |
| EP-1676846-A2 | Hydantoin derivatives as MMP inhibitors | AstraZeneca AB (SE) | 2006-07-05 | — | — | EP | disclosed |
| US-20040147573-A1 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2004-07-29 | — | — | US | disclosed |
| US-20040127528-A1 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003853-A1 | Metalloproteinase Inhibitors | MMP9, MMP12, MMP14 | MMP13 12/4885MMP12 2/4885MMP14 3/4885 |
| US-20080171882-A1 | Metalloproteinase Inhibitors | MMP9, MMP12, MMP14 | MMP13 12/4885MMP12 2/4885MMP14 3/4885 |
| US-20040127528-A1 | Metalloproteinase inhibitors | MMP9, MMP10, MMP3 | MMP13 10/4885MMP12 5/4885MMP14 6/4885 |
| US-20040147573-A1 | Metalloproteinase inhibitors | MMP12, MMP7, MMP10 | MMP13 19/4885MMP12 1/4885MMP14 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.