Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.48 |
| ▸ | HTR7 | P34969 | 4/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9385477 | 0.86 | KMT2A (0.49) | CACNA1GLMNAGAAALDH1A1HTR1A | |
| SCHEMBL9429617 | 0.81 | TSHR (0.62) | LMNAALDH1A1HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL9429271 | 0.80 | TSHR (0.65) | LMNAALDH1A1HTR1AHTR7 | |
| SCHEMBL9429270 | 0.78 | TP53 (0.60) | CACNA1GLMNAGAAALDH1A1 | |
| SCHEMBL9428373 | 0.77 | DRD2 (0.58) | LMNAALDH1A1HTR1AHTR7HPGD | |
| SCHEMBL9429935 | 0.76 | MAPT (0.57) | CACNA1GLMNAGAAALDH1A1ATM | |
| SCHEMBL9428483 | 0.76 | DRD2 (0.66) | LMNAHTR1A | |
| Hydrochloric Acid SCHEMBL9428467 | 0.76 | DRD2 (0.57) | LMNAALDH1A1HTR1AHTR7HPGD | |
| SCHEMBL9870796 | 0.75 | LMNA (0.50) | LMNAALDH1A1 | |
| SCHEMBL9428377 | 0.75 | CCR5 (0.44) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332739-A | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1994-07-26 | — | — | US | disclosed |
| EP-0454498-A2 | Pyrimidinedione derivatives and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-10-30 | — | — | EP | disclosed |