Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | CCR2 | P41597 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | APLNR | P35414 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1995839 | 0.89 | CYP3A4 (0.60) | ALDH1A1CYP3A4CYP1A2HPGDTDP1 | |
| SCHEMBL348805 | 0.82 | ALDH1A1 (0.52) | ALDH1A1CYP3A4CYP1A2HPGDTDP1 | |
| SCHEMBL29644492 | 0.82 | ALDH1A1 (0.52) | ALDH1A1CYP3A4CYP1A2HPGDTDP1 | |
| SCHEMBL1416730 | 0.82 | CYP3A4 (0.52) | ALDH1A1CYP3A4CYP1A2HPGDTDP1 | |
| SCHEMBL2001200 | 0.81 | ALDH1A1 (0.47) | ALDH1A1CYP3A4CYP1A2HPGDTDP1 | |
| SCHEMBL11514953 | 0.80 | ALDH1A1 (0.39) | ALDH1A1CYP3A4CYP1A2HPGDTDP1 | |
| SCHEMBL29449627 | 0.79 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP1A2HPGDTDP1 | |
| SCHEMBL17649855 | 0.79 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP1A2HPGDTDP1 | |
| SCHEMBL7808363 | 0.79 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP1A2HPGDTDP1 | |
| SCHEMBL11608792 | 0.79 | CYP3A4 (0.80) | ALDH1A1CYP3A4CYP1A2HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3296309-B1 | GALACTOPYRANOSYL DERIVATIVES USEFUL AS MEDICAMENTS | UNIV GENT (BE) | 2019-08-07 | — | — | EP | disclosed |
| US-10344016-B2 | Bromotriazole intermediates | AMGEN INC. (US) | 2019-07-09 | — | — | US | disclosed |
| US-20190100510-A1 | BROMOTRIAZOLE INTERMEDIATES | AMGEN INC. (US) | 2019-04-04 | — | — | US | disclosed |
| US-10221162-B2 | Triazole agonists of the APJ receptor | AMGEN INC. (US) | 2019-03-05 | — | — | US | disclosed |
| EP-3436429-A1 | BISCARBODIIMIDES AND POLYCARBODIIMIDES AND METHOD FOR THEIR PREPARATION | Dow Global Technologies, LLC (US) | 2019-02-06 | — | — | EP | disclosed |
| EP-3098226-B1 | BORATE-BASED BASE GENERATOR, AND BASE-REACTIVE COMPOSITION COMPRISING SUCH BASE GENERATOR | FUJIFILM WAKO PURE CHEMICAL CORP (JP) | 2018-12-12 | — | — | EP | disclosed |
| US-20180319773-A1 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-11-08 | — | — | US | disclosed |
| US-10100070-B2 | Borate-based base generator, and base-reactive composition comprising such base generator | FUJIFILM WAKO PURE CHEMICAL CORPORATION (JP) | 2018-10-16 | — | — | US | disclosed |
| CN-106414461-B | Borate-based generated base alkaline agent and alkali reactive composition containing the generated base alkaline agent | 富士胶片和光纯药株式会社 | 2018-09-11 | — | — | CN | disclosed |
| US-10058550-B2 | Methods of treating heart failure | AMGEN INC. (US) | 2018-08-28 | — | — | US | disclosed |
| US-20030207865-A1 | Substituted 2-arylimino heterocycles and compositions containing them for use as progesterone receptor binding agents | DIXON BRIAN R (US) | 2003-11-06 | — | — | US | disclosed |
| US-6353006-B1 | TREATMENT OF BONE DISORDERS, OSTEOPOROSIS AND HEALING AGENT | BAYER CORPORATION | 2002-03-05 | — | — | US | disclosed |
| EP-1144396-A2 | SUBSTITUTED 2-ARYLIMINO HETEROCYCLES AND COMPOSITIONS CONTAINING THEM, FOR USE AS PROGESTERONE RECEPTOR BINDING AGENTS | Bayer Corporation (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000042031-A2 | SUBSTITUTED 2-ARYLIMINO HETEROCYCLES AND COMPOSITIONS CONTAINING THEM, FOR USE AS PROGESTERONE RECEPTOR BINDING AGENTS | BAYER CORPORATION (US) | 2000-07-20 | — | — | WO | disclosed |
| US-5861517-A | INCREASING BLOOD SERUM HIGH DENSITY LIPOPROTEINS LEVELS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-01-19 | — | — | US | disclosed |
| EP-0876355-A1 | 2-THIOXO-IMIDAZOLIDIN-4-ONE DERIVATIVES AND THEIR USE FOR INCREASING HDL CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997019932-A1 | 2-THIOXO-IMIDAZOLIDIN-4-ONE DERIVATIVES AND THEIR USE FOR INCREASING HDL CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-06-05 | — | — | WO | disclosed |
| US-5585487-A | Method for the preparation of β-thiolactam compound | JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 1996-12-17 | — | — | US | disclosed |
| US-5554607-A | INCREASING HDL CHOLESTEROL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-09-10 | — | — | US | disclosed |
| US-4148799-A | Process for the preparation of 2-aryliminothiazoline solutions | BAYER AKTIENGESELLSCHAFT (DE) | 1979-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10100070-B2 | Borate-based base generator, and base-reactive composition comprising such base generator | BLM, HPRT1, BROX | ALDH1A1 2646/4885CYP3A4 3597/4885CYP1A2 3248/4885 |
| US-20180319773-A1 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | TBXA2R, AGTR1, AGTR2 | ALDH1A1 1773/4885CYP3A4 410/4885CYP1A2 218/4885 |
| US-20190100510-A1 | BROMOTRIAZOLE INTERMEDIATES | APH1A, BRDT, APH1B | ALDH1A1 2621/4885CYP3A4 579/4885CYP1A2 1401/4885 |
| US-10058550-B2 | Methods of treating heart failure | FABP3, TNNI3, APLNR | ALDH1A1 3046/4885CYP3A4 3671/4885CYP1A2 3209/4885 |
| US-10344016-B2 | Bromotriazole intermediates | APH1A, BRDT, APH1B | ALDH1A1 2621/4885CYP3A4 579/4885CYP1A2 1401/4885 |
| US-20030207865-A1 | Substituted 2-arylimino heterocycles and compositions containing them for use as progesterone receptor binding agents | PGR, PGRMC2, PGRMC1 | ALDH1A1 587/4885CYP3A4 199/4885CYP1A2 105/4885 |
| US-10221162-B2 | Triazole agonists of the APJ receptor | TBXA2R, AGTR1, AGTR2 | ALDH1A1 1773/4885CYP3A4 410/4885CYP1A2 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.