Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 3/20 | 0.55 |
| ▸ | CTSL | P07711 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MDH2 | P40926 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LTA4H | P09960 | 3/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15680424 | 0.85 | CTSV (0.48) | CTSVCTSLALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9425394 | 0.85 | ALDH1A1 (0.72) | CTSVCTSLALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL20022015 | 0.77 | HTR1D (0.57) | CTSVCTSLPOLBLTA4HPLA2G2A | |
| SCHEMBL17067000 | 0.77 | CTSV (0.58) | CTSVCTSLALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL2063876 | 0.77 | CTSV (0.64) | CTSVCTSLALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL256578 | 0.77 | CTSL (0.64) | CTSVCTSLALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7282665 | 0.76 | MTNR1A (0.53) | CTSVCTSLALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL12067617 | 0.76 | TRPM8 (0.70) | LTA4HPLA2G2AMAPTTRPM8KDM4E | |
| SCHEMBL5894674 | 0.76 | ALDH1A1 (0.51) | CTSVCTSLALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13931328 | 0.76 | KDM4E (0.54) | CTSVCTSLALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250691-A | Heteroaryl derivatives of monocyclic beta-lactam antibiotics | E. R. SQUIBB & SONS, INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0531976-A1 | Heteroaryl derivatives of monocyclic beta-lactam antibiotics | E.R. SQUIBB & SONS, INC. (US) | 1993-03-17 | — | — | EP | disclosed |