Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 3/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9450761 | 0.85 | HTR1A (0.41) | HTR1ASLC6A2POLBPDE9AKDM4E | |
| SCHEMBL9450885 | 0.84 | HTR1A (0.43) | HTR1ASLC6A2POLBPDE9AKDM4E | |
| SCHEMBL9450786 | 0.82 | SCN9A (0.41) | HTR1ASLC6A2POLBPDE9A | |
| SCHEMBL9683890 | 0.74 | ALDH1A1 (0.43) | KIF11HTR1ASLC6A2KDM4E | |
| SCHEMBL9733010 | 0.72 | RBP4 (0.50) | KIF11OXTRAVPR1ARORCKDM4E | |
| SCHEMBL9450752 | 0.69 | SLC6A2 (0.40) | HTR1ASLC6A2DRD3PDE9A | |
| SCHEMBL9354245 | 0.68 | OXTR (0.48) | KIF11OXTRAVPR1A | |
| SCHEMBL9450789 | 0.68 | POLB (0.37) | HTR1ASLC6A2POLBKDM4E | |
| SCHEMBL5363791 | 0.67 | HTR1A (0.58) | HTR1ASLC6A2 | |
| SCHEMBL10609153 | 0.67 | SCD (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0560905-A1 | 3-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY]-1-AZETIDINE CARBOXAMIDES HAVING ANTICONVULSANT ACTIVITY. | ROBINS CO INC A H (US) | 1993-09-22 | — | — | EP | disclosed |
| WO-1992010474-A1 | 3-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY]-1-AZETIDINE CARBOXAMIDES HAVING ANTICONVULSANT ACTIVITY | A.H. ROBINS COMPANY, INCORPORATED (US) | 1992-06-25 | — | — | WO | disclosed |
| US-5095014-A | 3-(2-chloro-4-(trifluoromethyl)phenoxy)-1-azetidine carboxamides having anticonvulsant activity | A. H. ROBINS COMPANY, INCORPORATED (US) | 1992-03-10 | — | — | US | disclosed |