Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9451687 | 0.77 | MCHR1 (0.57) | JAK2JAK3GPR119HDAC1GFER | |
| SCHEMBL2321959 | 0.73 | ADRB1 (0.45) | JAK2JAK3GPR119HDAC1ADRB2 | |
| SCHEMBL7302740 | 0.72 | JAK2 (0.44) | JAK2JAK3HDAC1ADRB2ADRB1 | |
| SCHEMBL9451750 | 0.72 | LSS (0.47) | JAK2JAK3HDAC1ADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL7307376 | 0.71 | MCHR1 (0.53) | ADRB2ADRB1ADRB3RAB9A | |
| SCHEMBL9451561 | 0.70 | DRD3 (0.46) | JAK2JAK3ADRB2ADRB1ADRB3 | |
| SCHEMBL28704613 | 0.70 | JAK2 (0.49) | JAK2JAK3GPR119HDAC1ADRB2 | |
| SCHEMBL7301452 | 0.70 | JAK2 (0.64) | JAK2JAK3HDAC1GFERADRB2 | |
| SCHEMBL7319744 | 0.70 | KDM4E (0.48) | JAK2JAK3ADRB2ADRB1ADRB3 | |
| SCHEMBL10676523 | 0.70 | GPR119 (0.62) | JAK2JAK3GPR119ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260318-A | Phenylpiperidylamines and drugs containing them | BASF AKTIENGESELLSCHAFT (DE) | 1993-11-09 | — | — | US | disclosed |