Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 2/20 | 0.57 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.57 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.57 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10447927 | 0.82 | FFAR2 (0.47) | ABCC9ABCC8KCNJ11KCNJ8ALDH1A1 | |
| SCHEMBL11078900 | 0.81 | NPC1 (0.60) | ABCC9ABCC8KCNJ11KCNJ8ALDH1A1 | |
| SCHEMBL11072102 | 0.79 | ALDH1A1 (0.63) | ALDH1A1HTTKDM4EMAPTHPGD | |
| SCHEMBL11072104 | 0.79 | ALDH1A1 (0.63) | ALDH1A1HTTKDM4EMAPTHPGD | |
| SCHEMBL15510403 | 0.79 | MAPT (0.74) | ALDH1A1KDM4EMAPTHPGDKMT2A | |
| SCHEMBL11156215 | 0.78 | ALDH1A1 (0.57) | ALDH1A1KDM4EMAPTHPGDNPC1 | |
| SCHEMBL11079424 | 0.78 | LMNA (0.56) | KMT2APKM | |
| SCHEMBL25994989 | 0.77 | KDM4E (0.53) | ABCC9ABCC8KCNJ11KCNJ8ALDH1A1 | |
| SCHEMBL11073535 | 0.77 | TSHR (0.60) | ALDH1A1HTTKDM4EMAPTHPGD | |
| SCHEMBL9426234 | 0.76 | ALDH1A1 (0.49) | ALDH1A1HTTMAPTHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381504-A2 | Improvements in and relating to guanidine derivatives | ELI LILLY AND COMPANY (US) | 1990-08-08 | — | — | EP | claimed |
| JP-2235868-A | — | — | None | — | — | JP | disclosed |
| US-5264445-A | Vasodilation | ELI LILLY AND COMPANY (US) | 1993-11-23 | — | — | US | disclosed |
| JP-H02235868-A | GUANIDINE DERIVATIVE | ELI LILLY & CO | 1990-09-18 | — | — | JP | disclosed |
| EP-0381504-A2 | Improvements in and relating to guanidine derivatives | ELI LILLY AND COMPANY (US) | 1990-08-08 | — | — | EP | disclosed |