Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRB1 | P17538 | 1/20 | 0.53 |
| ▸ | ECE1 | P42892 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.48 |
| ▸ | PRKG1 | Q13976 | 6/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 6/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 5/20 | 0.48 |
| ▸ | GSK3B | P49841 | 5/20 | 0.48 |
| ▸ | PRKACA | P17612 | 4/20 | 0.48 |
| ▸ | PRKX | P51817 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | GSK3A | P49840 | 4/20 | 0.48 |
| ▸ | SGK2 | Q9HBY8 | 4/20 | 0.48 |
| ▸ | IRAK1 | P51617 | 4/20 | 0.48 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PRKG2 | Q13237 | 5/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.43 |
| ▸ | AKT1 | P31749 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9458948 | 0.86 | CTRB1 (0.58) | CTRB1ECE1ROCK1ROCK2PRKG1 | |
| SCHEMBL9459397 | 0.83 | L3MBTL1 (0.43) | ROCK1ROCK2PRKG1PKN2CLK4 | |
| SCHEMBL9486724 | 0.80 | CTRB1 (0.54) | CTRB1ECE1ALDH1A1HPGDKMT2A | |
| SCHEMBL7357606 | 0.80 | CTRB1 (0.54) | CTRB1ECE1ALDH1A1HPGDKMT2A | |
| SCHEMBL9458824 | 0.78 | CTRB1 (0.49) | CTRB1ECE1ALDH1A1HPGD | |
| SCHEMBL9459389 | 0.78 | HTT (0.57) | CTRB1ECE1ALDH1A1HPGD | |
| SCHEMBL12518290 | 0.75 | CTSL (0.44) | ROCK1ROCK2PRKG1PKN2CLK4 | |
| SCHEMBL30780061 | 0.74 | HPGD (0.77) | ROCK1ROCK2PRKG1PKN2CLK4 | |
| SCHEMBL1568387 | 0.74 | HPGD (0.77) | ROCK1ROCK2PRKG1PKN2CLK4 | |
| SCHEMBL9322253 | 0.72 | CTRB1 (0.53) | CTRB1ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5232920-A | For treating hypertension and congestive heart failure in mammals | SCHERING CORPORATION (US) | 1993-08-03 | — | — | US | disclosed |