Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | SLC40A1 | Q9NP59 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15689758 | 0.82 | PKLR (0.62) | MEN1KMT2AATMGAASLC40A1 | |
| SCHEMBL15689701 | 0.80 | ALDH1A1 (0.69) | MEN1KMT2AATMGAASLC40A1 | |
| SCHEMBL29255666 | 0.80 | SLC40A1 (0.72) | MEN1KMT2AATMGAASLC40A1 | |
| SCHEMBL30854811 | 0.80 | SLC40A1 (0.72) | MEN1KMT2AATMGAASLC40A1 | |
| SCHEMBL9464640 | 0.80 | ACLY (0.62) | ALDH1A1TSHR | |
| SCHEMBL30854809 | 0.79 | SLC40A1 (0.76) | MEN1KMT2AATMGAASLC40A1 | |
| SCHEMBL1507919 | 0.79 | SLC40A1 (0.76) | MEN1KMT2AATMGAASLC40A1 | |
| SCHEMBL22315265 | 0.78 | ATM (0.74) | MEN1KMT2AATMGAASLC40A1 | |
| SCHEMBL22234047 | 0.78 | GAA (0.71) | MEN1KMT2AATMGAASLC40A1 | |
| SCHEMBL29540765 | 0.78 | GAA (0.71) | MEN1KMT2AATMGAASLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258399-A | 5-lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-11-02 | — | — | US | disclosed |
| US-5236948-A | Lipoxygenase inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| EP-0495594-A1 | Sulphonamide derivatives | ZENECA LIMITED (GB) | 1992-07-22 | — | — | EP | disclosed |