Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 3/20 | 0.38 |
| ▸ | CDK1 | P06493 | 3/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.38 |
| ▸ | GSK3A | P49840 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9452230 | 0.78 | KDM4E (0.61) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL10809192 | 0.76 | KDM4E (0.58) | HPGDLMNAKDM4EMEN1MAPK1 | |
| SCHEMBL9502884 | 0.75 | EIF4A3 (0.50) | CDK1GSK3AGSK3BCDK5HPGD | |
| SCHEMBL9501058 | 0.73 | GPR84 (0.41) | GSK3BHPGDLMNAKDM4EMEN1 | |
| SCHEMBL9502841 | 0.72 | CTSV (0.46) | HPGDLMNAALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL9500238 | 0.71 | PARP1 (0.31) | HPGDLMNAKDM4EMEN1MAPK1 | |
| SCHEMBL9452280 | 0.71 | KDM4E (0.47) | HPGDLMNAKDM4EMEN1MAPK1 | |
| SCHEMBL25936349 | 0.69 | KIF11 (0.52) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL9500206 | 0.67 | ALDH1A1 (0.49) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL9501343 | 0.67 | KDM4E (0.58) | HPGDKDM4EMEN1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303387-B1 | KYNURENIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | MERCK SHARP & DOHME LTD. (GB) | 1993-04-21 | — | — | EP | claimed |