Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4A3 | P38919 | 4/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9452239 | 0.78 | EIF4A3 (0.66) | EIF4A3KIF11KDM4EGAAMEN1 | |
| SCHEMBL10809192 | 0.76 | KDM4E (0.58) | KDM4EGAAMEN1KMT2AMAPT | |
| SCHEMBL9501058 | 0.76 | GPR84 (0.41) | GSK3BKDM4EMEN1KMT2ALMNA | |
| SCHEMBL9499282 | 0.75 | CCNB2 (0.38) | KIF11GSK3AGSK3BCDK5ALK | |
| SCHEMBL9502841 | 0.75 | CTSV (0.46) | LMNAHPGD | |
| SCHEMBL13024464 | 0.74 | LMNA (0.60) | EIF4A3KIF11AURKADAPK3JAK2 | |
| SCHEMBL9388968 | 0.74 | KIF11 (0.49) | EIF4A3KIF11AURKADAPK3JAK2 | |
| SCHEMBL9452225 | 0.72 | ALDH1A1 (0.48) | EIF4A3KIF11KDM4EGAAMEN1 | |
| SCHEMBL9500319 | 0.71 | CDK1 (0.37) | KMT2ACDK1CDK2 | |
| SCHEMBL9500206 | 0.69 | ALDH1A1 (0.49) | GSK3BKDM4EGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303387-B1 | KYNURENIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | MERCK SHARP & DOHME LTD. (GB) | 1993-04-21 | — | — | EP | claimed |