Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 5/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7749049 | 0.80 | TBXAS1 (0.52) | CHRNA7CHRNB2CHRNA4HTR6HTR2A | |
| SCHEMBL29415611 | 0.69 | ALDH1A1 (0.69) | HTR6MAPTMAPK1NPSR1ALDH1A1 | |
| SCHEMBL1424220 | 0.69 | ALDH1A1 (0.69) | HTR6MAPTMAPK1NPSR1ALDH1A1 | |
| SCHEMBL28022591 | 0.68 | MTNR1A (0.54) | CHRNA7CHRNB2CHRNA4HTR6MAPT | |
| Hydrochloric Acid SCHEMBL273338 | 0.67 | ALDH1A1 (0.67) | HTR6MAPTMAPK1NPSR1ALDH1A1 | |
| SCHEMBL16299526 | 0.67 | CYP19A1 (0.53) | CHRNA7CHRNB2CHRNA4HTR6MAPT | |
| SCHEMBL8253461 | 0.66 | CHRNB2 (0.56) | CHRNA7CHRNB2CHRNA4HTR6HTR2A | |
| SCHEMBL3886866 | 0.66 | HTR6 (0.63) | CHRNA7CHRNB2CHRNA4HTR6HTR2A | |
| SCHEMBL3228289 | 0.66 | CHRNB2 (0.67) | CHRNA7CHRNB2CHRNA4HTR6HTR2A | |
| SCHEMBL7650551 | 0.66 | HTR2A (0.59) | CHRNA7HTR2AHTR2CDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229505-A | CNS and cardiovascular effects | LABORATOIRES UPSA (FR) | 1993-07-20 | — | — | US | disclosed |