Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 5/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.51 |
| ▸ | CCKBR | P32239 | 6/20 | 0.47 |
| ▸ | CCKAR | P32238 | 1/20 | 0.41 |
| ▸ | PLD2 | O14939 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9499330 | 0.85 | CCKBR (0.58) | OPRD1OPRK1OPRM1CCKBRCCKAR | |
| SCHEMBL9499432 | 0.84 | OPRM1 (0.49) | OPRD1OPRK1OPRM1CCKBR | |
| SCHEMBL9501442 | 0.78 | CCKBR (0.62) | OPRK1CCKBRCCKAR | |
| Tifluadom SCHEMBL142031 | 0.75 | OPRD1 (1.00) | OPRD1OPRK1OPRM1CCKBRCCKAR | |
| Tifluadom SCHEMBL142030 | 0.75 | OPRD1 (1.00) | OPRD1OPRK1OPRM1CCKBRCCKAR | |
| SCHEMBL9501031 | 0.74 | CCKBR (0.64) | OPRK1OPRM1CCKBRCCKAR | |
| SCHEMBL9501463 | 0.73 | LMNA (0.52) | CCKBR | |
| SCHEMBL9683424 | 0.71 | CCKBR (0.38) | OPRK1CCKBR | |
| SCHEMBL9682641 | 0.69 | CCKBR (0.37) | CCKBR | |
| SCHEMBL19249829 | 0.69 | OPRD1 (0.84) | OPRD1OPRK1OPRM1CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486271-A2 | Cholecystokinin antagonists for treating neurological disorders | MERCK & CO. INC. (US) | 1992-05-20 | — | — | EP | claimed |
| US-5206238-A | Cholecystokinin antagonists | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0486271-A2 | Cholecystokinin antagonists for treating neurological disorders | MERCK & CO. INC. (US) | 1992-05-20 | — | — | EP | disclosed |
| US-4724237-A | GASTROINTESTINAL, CENTRAL NERVOUS, AND APPETITE DISORDERS | MERCK & CO., INC. (US) | 1988-02-09 | — | — | US | disclosed |
| EP-0166356-A2 | 2-Substituted-aminomethyl-1,4-benzodiazepines, process for their preparation and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-02 | — | — | EP | disclosed |