Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TET2 | Q6N021 | 4/20 | 0.33 |
| ▸ | TET3 | O43151 | 1/20 | 0.33 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.32 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.32 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7758820 | 0.87 | TET2 (0.40) | EGLN1ALOX15HSD17B10TET2TET3 | |
| SCHEMBL16661 | 0.87 | — | — | |
| Maleic Acid SCHEMBL2013518 | 0.86 | CAMK2A (0.42) | TSHRTP53EGLN1EGLN3ALOX15 | |
| Acrylic Acid SCHEMBL29373711 | 0.86 | ALOX15 (0.58) | TSHRALOX15HSD17B10TET2TET3 | |
| SCHEMBL29150247 | 0.85 | — | — | |
| SCHEMBL30849720 | 0.85 | — | — | |
| SCHEMBL4532573 | 0.85 | TET2 (0.39) | EGLN1ALOX15HSD17B10TET2TET3 | |
| Ethylene SCHEMBL7184477 | 0.85 | TET2 (0.39) | EGLN1ALOX15HSD17B10TET2TET3 | |
| Maleic Acid SCHEMBL2013642 | 0.85 | GPR84 (0.43) | TSHRTP53EGLN1EGLN3ALOX15 | |
| SCHEMBL5698428 | 0.82 | GRIK1 (0.41) | ALOX15HSD17B10TET2TET3TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0289788-B1 | HYDROSOLUBLE COPOLYMERS, PROCESS FOR THEIR PREPARATION AND THEIR USE | BASF Aktiengesellschaft (DE) | 1993-07-07 | — | — | EP | disclosed |
| EP-0289788-A2 | Hydrosoluble copolymers, process for their preparation and their use | BASF Aktiengesellschaft (DE) | 1988-11-09 | — | — | EP | disclosed |