Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 6/20 | 0.40 |
| ▸ | ACHE | P22303 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 5/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9503329 | 0.72 | KDM4E (0.36) | KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL9503522 | 0.70 | SIGMAR1 (0.52) | — | |
| SCHEMBL9505422 | 0.70 | BCHE (0.36) | BCHEACHEKDM4E | |
| SCHEMBL14463907 | 0.68 | LTA4H (0.57) | BCHEACHEKDM4EMEN1KMT2A | |
| SCHEMBL9503554 | 0.67 | NPC1 (0.35) | KDM4ESMN1; SMN2LMNACYP1A2CYP3A4 | |
| Succinic Acid SCHEMBL9503359 | 0.63 | ADRA1D (0.60) | KDM4ECYP3A4CYP2D6TSHRNFKB1 | |
| SCHEMBL868517 | 0.61 | THRB (0.59) | KDM4EMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9504438 | 0.61 | ADRA1D (0.69) | BCHEKDM4ECYP3A4CYP2D6TSHR | |
| SCHEMBL21195812 | 0.61 | KCNA3 (0.64) | KDM4EMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL29588544 | 0.61 | OPRK1 (0.48) | BCHEACHEFDPSESR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321967-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| EP-0321967-A2 | Compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | disclosed |