Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9506538 | 0.83 | ALDH1A1 (0.35) | NPC1LMNA | |
| SCHEMBL9503329 | 0.81 | KDM4E (0.36) | SMN1; SMN2KDM4E | |
| SCHEMBL9505422 | 0.79 | BCHE (0.36) | KDM4E | |
| SCHEMBL9505420 | 0.79 | KDM4E (0.37) | SMN1; SMN2KDM4E | |
| SCHEMBL9503551 | 0.75 | SIGMAR1 (0.41) | — | |
| SCHEMBL9503527 | 0.67 | BCHE (0.40) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9503326 | 0.62 | SIGMAR1 (0.45) | — | |
| SCHEMBL9505418 | 0.62 | SIGMAR1 (0.43) | KDM4E | |
| SCHEMBL9505419 | 0.61 | NCEH1 (0.45) | — | |
| SCHEMBL9503683 | 0.60 | DRD2 (0.64) | CYP3A4CYP2D6NFKB1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321967-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |