Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502176 | 0.96 | KDM4E (0.48) | KDM4ETDP1CYP2D6PKMTP53 | |
| SCHEMBL9502751 | 0.86 | KDM4E (0.39) | KDM4ETDP1CYP2D6USP2TSHR | |
| SCHEMBL9501107 | 0.84 | TSHR (0.48) | KDM4ETDP1USP2TSHRL3MBTL1 | |
| SCHEMBL10518194 | 0.78 | LMNA (0.46) | KDM4ETDP1KMT2AALDH1A1LMNA | |
| SCHEMBL9502822 | 0.77 | LMNA (0.50) | KDM4EKMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9502192 | 0.77 | TDP1 (0.43) | KDM4ETDP1CYP2D6USP2L3MBTL1 | |
| SCHEMBL9501073 | 0.74 | GAA (0.59) | CYP2D6PKMKMT2AALDH1A1LMNA | |
| SCHEMBL9504119 | 0.73 | CYP2D6 (0.44) | KDM4ECYP2D6USP2CYP3A4TSHR | |
| SCHEMBL12726868 | 0.70 | CYP2D6 (0.76) | CYP2D6USP2CYP3A4TSHRCYP2C19 | |
| SCHEMBL9502196 | 0.68 | CYP2D6 (0.47) | KDM4ECYP2D6L3MBTL1PKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330910-B1 | PROPANE DERIVATIVES | KOWA COMPANY, LTD. (JP) | 1993-05-12 | — | — | EP | claimed |
| US-4960883-A | Cardiovascular disorders | KOWA COMPANY, LTD. (JP) | 1990-10-02 | — | — | US | claimed |
| EP-0330910-B1 | PROPANE DERIVATIVES | KOWA COMPANY, LTD. (JP) | 1993-05-12 | — | — | EP | disclosed |
| US-4960883-A | Cardiovascular disorders | KOWA COMPANY, LTD. (JP) | 1990-10-02 | — | — | US | disclosed |
| EP-0330910-A1 | Propane derivatives | KOWA COMPANY, LTD. (JP) | 1989-09-06 | — | — | EP | disclosed |