Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | BMP1 | P13497 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CMA1 | P23946 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9510979 | 0.77 | MMP1 (0.42) | MMP1BMP1MEN1KMT2AGAA | |
| SCHEMBL9509591 | 0.65 | FFAR1 (0.39) | MMP1GAAL3MBTL1 | |
| SCHEMBL9510871 | 0.63 | ALDH1A1 (0.40) | MMP1MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL9511010 | 0.63 | IDO1 (0.42) | MMP1MEN1KMT2A | |
| Anisole SCHEMBL7204405 | 0.61 | CA4 (0.50) | ALDH1A1 | |
| SCHEMBL9507230 | 0.61 | CTSB (0.40) | MEN1KMT2AGAAALDH1A1HTT | |
| SCHEMBL7314497 | 0.61 | AKR1C3 (0.40) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL2433696 | 0.59 | ACP3 (0.56) | KMT2AALDH1A1TDP1L3MBTL1NPC1 | |
| SCHEMBL7948715 | 0.58 | CA1 (0.58) | GAAALDH1A1KDM4ETDP1L3MBTL1 | |
| SCHEMBL5208103 | 0.58 | LDHA (0.55) | ALDH1A1KDM4EHTTLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358305-B1 | MERCAPTO-PHENYLALCANOYLAMINO ACID AMIDES, THEIR PREPARATION AND THEIR USE AS COLLAGENASE INHIBITORS | BEECHAM GROUP PLC (GB) | 1993-08-25 | — | — | EP | disclosed |
| US-5124322-A | Antiarthritic agents | BEECHAM GROUP P.L.C. (GB) | 1992-06-23 | — | — | US | disclosed |
| EP-0358305-A1 | Mercapto-phenylalcanoylamino acid amides, their preparation and their use as collagenase inhibitors | BEECHAM GROUP PLC (GB) | 1990-03-14 | — | — | EP | disclosed |