SCHEMBL951323

SCHEMBL951323

Cn1nc(C(F)(F)F)cc1C(=O)Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.50
GRN P28799 1/20 0.50
SORT1 Q99523 1/20 0.50
ALDH1A1 P00352 3/20 0.46
CYP3A4 P08684 1/20 0.46
HSD17B10 Q99714 1/20 0.46
POLB P06746 1/20 0.46
RAB9A P51151 2/20 0.45
NPC1 O15118 1/20 0.45
KCNT1 Q5JUK3 7/20 0.44
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
HDAC9 Q9UKV0 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17920 0.84 GRN (0.71) KDM4EGRNSORT1ALDH1A1CYP3A4
SCHEMBL350765 0.84 GRN (0.71) KDM4EGRNSORT1RAB9ACTSL
SCHEMBL13064210 0.84 KDM4E (0.51) KDM4EGRNSORT1ALDH1A1CYP3A4
SCHEMBL17732 0.82 KDM4E (0.50) KDM4EGRNSORT1ALDH1A1CYP3A4
Hydrochloric Acid SCHEMBL8932269 0.82 GRN (0.69) KDM4EGRNSORT1ALDH1A1CYP3A4
SCHEMBL13020360 0.81 KDM4E (0.53) KDM4EGRNSORT1ALDH1A1CYP3A4
SCHEMBL30305711 0.81 KDM4E (0.49) KDM4EGRNSORT1ALDH1A1CYP3A4
SCHEMBL19902317 0.79 ALDH1A1 (0.50) KDM4EGRNSORT1ALDH1A1CYP3A4
SCHEMBL19994223 0.79 KDM4E (0.47) KDM4EGRNSORT1ALDH1A1CYP3A4
SCHEMBL17452578 0.79 KDM4E (0.47) KDM4EGRNSORT1ALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116217467-A ERDRP-0519 intermediate and preparation method thereof 烟台皓元生物医药科技有限公司 2023-06-06 CN claimed
CN-116217467-A ERDRP-0519 intermediate and preparation method thereof 烟台皓元生物医药科技有限公司 2023-06-06 CN disclosed
EP-2771324-B1 MYXOVIRUS THERAPEUTICS, COMPOUNDS, AND USES RELATED THERETO UNIV EMORY (US) 2017-02-01 EP disclosed
US-9499489-B2 Myxovirus therapeutics, compounds, and uses related thereto EMORY UNIVERSITY (US) 2016-11-22 US disclosed
US-20140329817-A1 MYXOVIRUS THERAPEUTICS, COMPOUNDS, AND USES RELATED THERETO CHILDREN'S HEATLHCARE OF ATLANTA, INC. (US) 2014-11-06 US disclosed
US-8541406-B2 Thiadiazole derivatives for the treatment of neurodegenerative diseases NV REMYND (BE) 2013-09-24 US disclosed
CN-101287721-B Hydrazide compound and pesticidal use of the same SUMITOMO CO LTD 2013-03-27 CN disclosed
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 EP disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 US disclosed
US-20100137314-A1 HARMFUL ORGANISM CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-03 US disclosed
US-20100099692-A1 HARMFUL ORGANISM CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-04-22 US disclosed
US-20090233911-A2 THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES NV REMYND (BE) 2009-09-17 US disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed
US-20090054410-A1 THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES NV REMYND (BE) 2009-02-26 US disclosed
CN-101287721-A Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL CO (JP) 2008-10-15 CN disclosed
EP-1937664-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME Sumitomo Chemical Company, Limited (JP) 2008-07-02 EP disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed
US-5498624-A PLANT FUNGICIDES MONSANTO COMPANY (US) 1996-03-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100099692-A1 HARMFUL ORGANISM CONTROL COMPOSITION UQCRC1, UQCRC2, Q6ZSR9 KDM4E 2026/4885GRN 2842/4885SORT1 4869/4885
US-20090233911-A2 THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES SNCA, HTT, PARK7 KDM4E 4164/4885GRN 596/4885SORT1 772/4885
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 KDM4E 1084/4885GRN 4817/4885SORT1 4826/4885
US-20100137314-A1 HARMFUL ORGANISM CONTROL COMPOSITION UQCRC2, UQCRC1, UQCRB KDM4E 2615/4885GRN 2562/4885SORT1 4868/4885
US-20140329817-A1 MYXOVIRUS THERAPEUTICS, COMPOUNDS, AND USES RELATED THERETO RPP30, RNASE1, MAVS KDM4E 1229/4885GRN 3463/4885SORT1 2931/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT KDM4E 2028/4885GRN 4722/4885SORT1 4772/4885
US-20090054410-A1 THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES SNCA, HTT, PARK7 KDM4E 4164/4885GRN 596/4885SORT1 772/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.