Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.44 |
| ▸ | RAB9A | P51151 | 12/20 | 0.44 |
| ▸ | POLB | P06746 | 5/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516597 | 0.74 | DAO (0.66) | — | |
| SCHEMBL1928504 | 0.73 | GAA (0.67) | NPC1RAB9ASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL9515320 | 0.73 | ALDH1A1 (0.44) | NPC1RAB9APOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL9630876 | 0.71 | RAB9A (0.77) | NPC1RAB9APOLBSMN1; SMN2TDP1 | |
| SCHEMBL9630236 | 0.71 | NPC1 (0.45) | NPC1RAB9APOLBSMN1; SMN2TDP1 | |
| SCHEMBL10770200 | 0.71 | NPC1 (0.51) | NPC1RAB9APOLBSMN1; SMN2TDP1 | |
| SCHEMBL9630186 | 0.71 | MAOB (0.53) | RAB9APOLBSMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL9632286 | 0.71 | MAOB (0.53) | RAB9APOLBSMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL9630176 | 0.70 | NPC1 (0.60) | NPC1RAB9APOLBSMN1; SMN2TDP1 | |
| SCHEMBL68570 | 0.70 | ALOX5 (0.69) | NPC1RAB9ASMN1; SMN2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0236624-B1 | SUBSTITUTED PHENYL ETHANOL AMINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1993-08-11 | — | — | EP | disclosed |
| US-5153210-A | Hypoglycemic agent, animal growth regulator; veterinary medicine | BEECHAM GROUP P.L.C. (GB) | 1992-10-06 | — | — | US | disclosed |
| EP-0236624-A2 | Substituted phenyl ethanol amines, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1987-09-16 | — | — | EP | disclosed |