Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LNPEP | Q9UIQ6 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566906 | 0.82 | SPHK2 (0.45) | LNPEP | |
| SCHEMBL9566784 | 0.80 | LMNA (0.44) | LNPEPMEN1KMT2AKDM4EMAPT | |
| SCHEMBL9517033 | 0.79 | KDM4C (0.52) | TSHRMEN1KMT2ANR4A2SRD5A2 | |
| SCHEMBL9519559 | 0.78 | P4HTM (0.49) | TSHRMEN1KMT2ANR4A2SRD5A2 | |
| SCHEMBL9566730 | 0.78 | KDM4E (0.45) | LNPEPMEN1KMT2AKDM4EKDM4C | |
| SCHEMBL9566767 | 0.77 | NOS3 (0.38) | LNPEPKDM4EKDM5AKDM4CKDM5B | |
| SCHEMBL9367677 | 0.75 | KMT2A (0.49) | TSHRMEN1KMT2ASRD5A2P4HTM | |
| SCHEMBL14276269 | 0.74 | TSHR (0.50) | TSHRKMT2AKDM4EMAPTGRM5 | |
| SCHEMBL9845133 | 0.72 | KMT2A (0.52) | TSHRMEN1KMT2AKDM5AKDM4C | |
| SCHEMBL9673277 | 0.71 | TSHR (0.60) | TSHRMEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |
| EP-0533130-A1 | 2-Hydroxymethylpyridines, the corresponding pyridine-N-oxides and derivatives thereof, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-24 | — | — | EP | disclosed |