Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516093 | 0.91 | HSD11B1 (0.43) | HDAC1HDAC6HDAC3HDAC2P4HTM | |
| SCHEMBL9519398 | 0.90 | SCD (0.41) | HDAC1HDAC6HDAC3HDAC2HDAC5 | |
| SCHEMBL9519641 | 0.87 | SCD (0.41) | HDAC1HDAC6HDAC3HDAC2HDAC5 | |
| SCHEMBL9517180 | 0.86 | PNMT (0.44) | HDAC1HDAC6HDAC3HDAC2HDAC5 | |
| SCHEMBL9517165 | 0.84 | VNN1 (0.40) | HDAC1HDAC6HDAC3HDAC2VNN1 | |
| SCHEMBL9519638 | 0.83 | BCL2L1 (0.42) | HDAC1HDAC6P4HTMBCL2L1MCL1 | |
| SCHEMBL9515738 | 0.82 | P4HTM (0.43) | HDAC6P4HTMSLC6A9BCL2L1MCL1 | |
| SCHEMBL9516012 | 0.79 | HSD11B1 (0.39) | HDAC1HDAC6HDAC3HDAC2P4HTM | |
| SCHEMBL9566750 | 0.78 | MEN1 (0.54) | MRGPRX4 | |
| SCHEMBL9516266 | 0.78 | GRM5 (0.38) | HDAC6P4HTMSLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |