Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.51 |
| ▸ | CTSL | P07711 | 2/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | TACR1 | P25103 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.48 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8248610 | 0.86 | CTSS (0.54) | CTSSCTSLSYKATMTACR1 | |
| SCHEMBL11921047 | 0.83 | NPC1 (0.52) | CTSSCTSLSYKATMTACR1 | |
| SCHEMBL11920721 | 0.82 | CTSK (0.53) | CTSSCTSLATMCTSBMEN1 | |
| SCHEMBL29860837 | 0.82 | CTSB (0.52) | CTSSCTSLATMCYP3A4CYP2C9 | |
| SCHEMBL8427919 | 0.82 | MEN1 (0.53) | CTSSSYKALDH1A1POLBMEN1 | |
| SCHEMBL29634392 | 0.81 | CTRB1 (0.51) | CTSSCTSLSYKCTSBMEN1 | |
| SCHEMBL31326042 | 0.81 | MEN1 (0.52) | CTSSCTSLSYKALDH1A1POLB | |
| SCHEMBL8094326 | 0.81 | MMP2 (0.57) | CTSSCTSLSYKATMCYP3A4 | |
| SCHEMBL3100721 | 0.80 | CTRB1 (0.54) | CTSSCTSLCTSBMEN1KMT2A | |
| SCHEMBL8699825 | 0.80 | CTSL (0.52) | CTSSCTSLCTSBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0333938-B1 | 2-HYDROXY-3-ARYLOXY-PROPYLAMINE DERIVATIVES HAVING CARDIOVASCULAR ACTIVITY | ZAMBON GROUP S.p.A. (IT) | 1993-04-14 | — | — | EP | disclosed |
| US-5047425-A | Amine derivatives having cardiovascular activity | SIMES SOCIETA ITALIANA MEDICINALI & SINTETICI SPA (IT) | 1991-09-10 | — | — | US | disclosed |
| EP-0333938-A1 | 2-Hydroxy-3-aryloxy-propylamine derivatives having cardiovascular activity | ZAMBON GROUP S.p.A. (IT) | 1989-09-27 | — | — | EP | disclosed |