Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18041437 | 0.95 | MAOA (0.51) | MAOAMAOBKDM4EPOLBL3MBTL1 | |
| SCHEMBL1027287 | 0.90 | MAOA (0.56) | MAOAMAOBNPC1RAB9AHPGD | |
| SCHEMBL27129577 | 0.82 | HDAC6 (0.55) | KDM4EPOLBL3MBTL1NPC1RAB9A | |
| SCHEMBL378759 | 0.82 | NPC1 (0.62) | KDM4EPOLBL3MBTL1NPC1RAB9A | |
| SCHEMBL16594295 | 0.82 | MTNR1A (0.50) | MAOAMAOBKDM4EPOLBNPC1 | |
| SCHEMBL3134457 | 0.82 | POLB (0.49) | MAOAMAOBPOLBMTNR1AMTNR1B | |
| SCHEMBL1231292 | 0.81 | CYP1A2 (0.65) | MAOAMAOBKDM4EHPGDCYP2D6 | |
| SCHEMBL164622 | 0.81 | L3MBTL1 (0.72) | KDM4EPOLBL3MBTL1NPC1RAB9A | |
| SCHEMBL1794493 | 0.81 | NPC1 (0.52) | KDM4EPOLBL3MBTL1NPC1RAB9A | |
| SCHEMBL7839606 | 0.80 | HPGD (0.62) | MAOAMAOBKDM4EL3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250467-A2 | INHIBITORS OF ANTIMICROBIAL RESISTANCE AND METHODS USING SAME | BAYLOR COLLEGE OF MEDICINE (US) | 2023-12-28 | — | — | WO | disclosed |
| WO-2023113456-A1 | NOVEL COMPOUND FOR DEGRADING TARGET PROTEIN OR POLYPEPTIDE BY USING POLYUBIQUITINATION | (주)프레이저테라퓨틱스 | 2023-06-22 | — | — | WO | disclosed |
| EP-3265458-B1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-12-19 | — | — | EP | disclosed |
| EP-3265458-A1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2018-01-10 | — | — | EP | disclosed |
| US-9822065-B1 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-11-21 | — | — | US | disclosed |
| US-9597333-B2 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-03-21 | — | — | US | disclosed |
| US-20170014423-A1 | Benzazepine Dicarboxamide Compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-01-19 | — | — | US | disclosed |
| US-9475775-B2 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-10-25 | — | — | US | disclosed |
| WO-2016142250-A1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-09-15 | — | — | WO | disclosed |
| US-20160257653-A1 | Benzazepine Dicarboxamide Compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-09-08 | — | — | US | disclosed |
| US-7842711-B2 | Indazolecarboxamide derivatives for the treatment and prevention of malaria | SANOFI-AVENTIS (FR) | 2010-11-30 | — | — | US | disclosed |
| WO-2010048332-A2 | COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| CN-101646427-A | Inhibitors of akt activity | SMITHKLINE BEECHAM CORP US | 2010-02-10 | — | — | CN | disclosed |
| US-7482342-B2 | Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors | SANOFI-AVENTIS (FR) | 2009-01-27 | — | — | US | disclosed |
| US-20070185187-A1 | INDAZOLECARBOXAMIDE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF MALARIA | SANOFI-AVENTIS (FR) | 2007-08-09 | — | — | US | disclosed |
| EP-1727544-A1 | USE OF INDAZOLECARBOXAMIDE DERIVATIVES FOR THE PREPARATION OF A MEDICAMENT THAT IS INTENDED FOR THE TREATMENT AND PREVENTION OF PALUDISM | Sanofi-Aventis (FR) | 2006-12-06 | — | — | EP | disclosed |
| US-20060004000-A1 | Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors | SANOFI-AVENTIS (FR) | 2006-01-05 | — | — | US | disclosed |
| WO-2005099703-A1 | USE OF INDAZOLECARBOXAMIDE DERIVATIVES FOR THE PREPARATION OF A MEDICAMENT THAT IS INTENDED FOR THE TREATMENT AND PREVENTION OF PALUDISM | SANOFI-AVENTIS (FR) | 2005-10-27 | — | — | WO | disclosed |
| EP-1549620-A1 | INDAZOLECARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF AS CDK1, CDK2 AND CDK4 INHIBITORS | Sanofi-Aventis (FR) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004031158-A1 | INDAZOLECARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF AS CDK1, CDK2 AND CDK4 INHIBITORS | SANOFI-AVENTIS (FR) | 2004-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170014423-A1 | Benzazepine Dicarboxamide Compounds | TLR1, TLR4, TLR5 | MAOA 3134/4885MAOB 2967/4885KDM4E 598/4885 |
| US-20070185187-A1 | INDAZOLECARBOXAMIDE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF MALARIA | CYP3A43, CYP3A5, SIRT5 | MAOA 1543/4885MAOB 2017/4885KDM4E 2696/4885 |
| US-20160257653-A1 | Benzazepine Dicarboxamide Compounds | TLR1, TLR4, TLR5 | MAOA 3134/4885MAOB 2967/4885KDM4E 598/4885 |
| US-20060004000-A1 | Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors | CDK2, CDK1, CDK4 | MAOA 3275/4885MAOB 2982/4885KDM4E 2725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.