Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TLR3 | O15455 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527983 | 0.88 | TLR3 (0.40) | MAPTALDH1A1KDM4EL3MBTL1TP53 | |
| SCHEMBL9524511 | 0.82 | TLR3 (0.39) | MAPTALDH1A1L3MBTL1SMN1; SMN2TLR3 | |
| SCHEMBL9525760 | 0.81 | TRPM5 (0.42) | TP53SMN1; SMN2SIRT2NPSR1LMNA | |
| SCHEMBL9524374 | 0.81 | HTR2B (0.35) | MAPTSMN1; SMN2 | |
| SCHEMBL9523567 | 0.80 | DDB1 (0.38) | ALDH1A1KDM4ESMN1; SMN2KMT2AHTT | |
| SCHEMBL9524902 | 0.80 | ESR1 (0.42) | KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL9527411 | 0.80 | BRD4 (0.37) | KDM4ESMN1; SMN2 | |
| SCHEMBL9527547 | 0.79 | ALDH1A1 (0.40) | MAPTALDH1A1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL9523546 | 0.79 | TGFBR1 (0.39) | MAPTALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL8967989 | 0.78 | ABCC9 (0.43) | KDM4ESIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1030582-A | 1-benzopyran derivatives | HOFFMANN LA ROCHE (CH) | 1989-01-25 | — | — | CN | claimed |
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | disclosed |
| US-5118694-A | Hypotensive agents; treatment for cardiovascular and muscular disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971982-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-11-20 | — | — | US | disclosed |
| EP-0298452-A2 | 2H-1-benzopyrane derivatives substituted in position 4 by aryl or N-heteroaryl | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-11 | — | — | EP | disclosed |