Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | DPYD | Q12882 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | UPP1 | Q16831 | 1/20 | 0.34 |
| ▸ | GALR3 | O60755 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 2/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3479396 | 0.79 | KDM4E (0.53) | KDM4EALDH1A1GAAL3MBTL1GLA | |
| SCHEMBL9529307 | 0.75 | KDM4E (0.55) | KDM4EALDH1A1GAAL3MBTL1GLA | |
| SCHEMBL11008749 | 0.72 | MCL1 (0.51) | KDM4EALDH1A1GAAL3MBTL1GLA | |
| SCHEMBL9529006 | 0.70 | MDM2 (0.47) | KDM4EALDH1A1GAAL3MBTL1GLA | |
| SCHEMBL8064436 | 0.70 | PIM1 (0.56) | KDM4EALDH1A1GAAL3MBTL1GLA | |
| SCHEMBL2869595 | 0.69 | TRPV4 (0.46) | — | |
| SCHEMBL4474609 | 0.68 | MDM2 (0.62) | KDM4EALDH1A1GAAL3MBTL1GLA | |
| SCHEMBL9702588 | 0.68 | ALPL (0.32) | ALDH1A1AHRCES1 | |
| SCHEMBL9754547 | 0.68 | MCL1 (0.55) | KDM4EALDH1A1GAAL3MBTL1GLA | |
| SCHEMBL9525290 | 0.68 | KDM4E (0.64) | KDM4EALDH1A1GAAL3MBTL1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550576-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992006085-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-04-16 | — | — | WO | disclosed |