Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | STK4 | Q13043 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9701293 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL9525349 | 0.78 | ALDH1A1 (0.44) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL9526870 | 0.78 | GABRA1 (0.40) | GABRA1GABRB2PDE3BPDE3APDE5A | |
| SCHEMBL9701626 | 0.76 | ALDH1A1 (0.56) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL11118460 | 0.70 | PGR (0.49) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL11110995 | 0.69 | ALDH1A1 (0.58) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL9701832 | 0.68 | KDM4E (0.77) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL9525396 | 0.68 | ALDH1A1 (0.49) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL9525387 | 0.68 | ALDH1A1 (0.49) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL9526574 | 0.67 | KDM4E (0.56) | ALDH1A1KDM4EGLAGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550576-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992006085-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-04-16 | — | — | WO | disclosed |