Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9051635 | 0.96 | THRB (0.35) | SMN1; SMN2BCL2MEN1KMT2ANLRP3 | |
| SCHEMBL29384283 | 0.96 | THRB (0.35) | SMN1; SMN2BCL2MEN1KMT2ANLRP3 | |
| Hydrochloric Acid SCHEMBL9523909 | 0.89 | MEN1 (0.38) | SMN1; SMN2MEN1KMT2AALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL9525176 | 0.86 | LMNA (0.37) | SMN1; SMN2MEN1KMT2APRMT5WDR77 | |
| SCHEMBL9526836 | 0.84 | SMN1; SMN2 (0.50) | SMN1; SMN2BCL2MEN1KMT2ANLRP3 | |
| Hydrochloric Acid SCHEMBL9526084 | 0.81 | HDAC1 (0.35) | SMN1; SMN2MEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL9525649 | 0.80 | ADRA2A (0.32) | MEN1KMT2AALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL9523922 | 0.80 | TSHR (0.33) | TSHR | |
| SCHEMBL9528889 | 0.79 | TSHR (0.33) | TSHR | |
| Hydrochloric Acid SCHEMBL9525326 | 0.79 | MEN1 (0.34) | SMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0382380-B1 | PYRIDINIUM NITRATE, ITS PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1993-09-01 | — | — | EP | disclosed |
| US-4981860-A | ANTICOAGULANTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-01-01 | — | — | US | disclosed |
| EP-0382380-A1 | Pyridinium Nitrate, its production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-08-16 | — | — | EP | disclosed |