Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527037 | 0.93 | DRD2 (0.49) | DRD2DRD4ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL9527777 | 0.84 | KAT2B (0.57) | DRD2DRD4HTR2AHTR1AHTR2C | |
| SCHEMBL9529034 | 0.83 | ADRA1A (0.56) | DRD2ALDH1A1CYP2D6CYP2C9HTR2A | |
| SCHEMBL9528344 | 0.81 | ADRA1D (0.48) | DRD2HTR2AHTR1AHTR7SMN1; SMN2 | |
| SCHEMBL9528237 | 0.79 | POLB (0.51) | DRD2HTR2AHTR1AHTR2CHTR7 | |
| SCHEMBL9527503 | 0.79 | ADRA1A (0.57) | DRD2HTR1AHTR7 | |
| SCHEMBL9531299 | 0.79 | ADRA1A (0.69) | DRD2CYP2C9HTR2AHTR1AHTR7 | |
| SCHEMBL9529414 | 0.78 | ALOX15 (0.50) | DRD2DRD4ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL9528853 | 0.77 | KAT2B (0.60) | DRD2HTR2ATP53HRH1 | |
| SCHEMBL9527073 | 0.76 | HTR1A (0.65) | DRD2DRD4CYP2C9HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |