Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 4/20 | 0.57 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532001 | 0.94 | KAT2B (0.59) | KAT2BBRD4BRD9DRD3HTR1A | |
| SCHEMBL9528237 | 0.85 | POLB (0.51) | POLBKCNH2DRD3HTR1AHTR2A | |
| SCHEMBL9528713 | 0.83 | BRD4 (0.55) | KAT2BBRD4BRD9DRD3HTR1A | |
| SCHEMBL9528374 | 0.82 | DRD2 (0.58) | KAT2BBRD4BRD9DRD3HTR1A | |
| SCHEMBL9527001 | 0.80 | ADRA1A (0.63) | DRD3HTR1ADRD2SLC6A4 | |
| SCHEMBL9528982 | 0.80 | POLB (0.52) | POLBKCNH2DRD3HTR1AHTR2A | |
| SCHEMBL9528850 | 0.80 | BPTF (0.49) | KAT2BPOLBDRD3HTR1AHTR2A | |
| SCHEMBL9527777 | 0.80 | KAT2B (0.57) | KAT2BBRD4BRD9DRD3HTR1A | |
| SCHEMBL9526815 | 0.79 | HTR1A (0.47) | POLBKCNH2HTR1AHTR7 | |
| SCHEMBL9531572 | 0.79 | KAT2B (0.58) | KAT2BBRD4BRD9HTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |