Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 7/20 | 0.49 |
| ▸ | HTR2A | P28223 | 6/20 | 0.49 |
| ▸ | DRD3 | P35462 | 6/20 | 0.49 |
| ▸ | DRD2 | P14416 | 5/20 | 0.49 |
| ▸ | HTR7 | P34969 | 4/20 | 0.49 |
| ▸ | HTR2C | P28335 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | DRD1 | P21728 | 3/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.47 |
| ▸ | DRD5 | P21918 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529080 | 0.94 | POLB (0.48) | POLBHTR1AHTR2ADRD3DRD2 | |
| SCHEMBL9529414 | 0.80 | ALOX15 (0.50) | HTR1AHTR2ADRD3DRD2HTR7 | |
| SCHEMBL9526962 | 0.80 | KAT2B (0.57) | POLBSLC6A4HTR1AHTR2ADRD3 | |
| SCHEMBL9528291 | 0.80 | HTR1A (0.63) | SLC6A4HTR1AHTR2ADRD3DRD2 | |
| SCHEMBL9528237 | 0.79 | POLB (0.51) | POLBSLC6A4HTR1AHTR2ADRD3 | |
| SCHEMBL9527520 | 0.78 | HTR7 (0.55) | HTR1ADRD2HTR7KCNH2SIGMAR1 | |
| SCHEMBL9531342 | 0.77 | HTR1A (0.60) | SLC6A4HTR1AHTR2ADRD3DRD2 | |
| SCHEMBL9527638 | 0.76 | HTR1A (0.61) | SLC6A4HTR1AHTR2ADRD3DRD2 | |
| SCHEMBL9527885 | 0.75 | ADRA1B (0.49) | HTR1ADRD3DRD2HTR7 | |
| SCHEMBL5926121 | 0.75 | HTR1A (0.46) | POLBSLC6A4HTR1AHTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |