Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526815 | 0.93 | HTR1A (0.47) | POLBKCNH2HTR7HTR1A | |
| SCHEMBL9526962 | 0.85 | KAT2B (0.57) | POLBKCNH2SLC6A4DRD3HTR7 | |
| SCHEMBL9527503 | 0.83 | ADRA1A (0.57) | DRD3HTR7HTR1ADRD2 | |
| SCHEMBL9529034 | 0.82 | ADRA1A (0.56) | DRD3HTR7HTR1AHTR2ADRD2 | |
| SCHEMBL9531299 | 0.80 | ADRA1A (0.69) | SLC6A4DRD3HTR7HTR1AHTR2A | |
| SCHEMBL9528837 | 0.79 | DRD2 (0.48) | HTR7HTR1AHTR2ADRD2HTR2C | |
| SCHEMBL9528982 | 0.79 | POLB (0.52) | POLBKCNH2SLC6A4DRD3HTR7 | |
| SCHEMBL9532001 | 0.79 | KAT2B (0.59) | DRD3HTR7HTR1AHTR2ADRD2 | |
| SCHEMBL9528344 | 0.78 | ADRA1D (0.48) | KCNH2HTR7HTR1AHTR2ADRD2 | |
| SCHEMBL9527073 | 0.77 | HTR1A (0.65) | DRD3HTR7HTR1AHTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |