Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529716 | 0.89 | KCNH2 (0.50) | DRD4DRD2ADRA2AADRA2BADRA2C | |
| SCHEMBL9530044 | 0.84 | ABCB1 (0.49) | DRD4DRD2DRD3ADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL10368330 | 0.82 | ABCB1 (0.48) | DRD4DRD2DRD3ADRA2AADRA2B | |
| SCHEMBL10677091 | 0.82 | ADRA2A (0.59) | KDM4EGBA1DRD2ADRA2AADRA2B | |
| SCHEMBL9696810 | 0.79 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CHTR1ASIGMAR1 | |
| SCHEMBL9455117 | 0.78 | CASR (0.45) | LMNADRD4DRD2DRD3ADRA2A | |
| SCHEMBL9455118 | 0.76 | ADRA2A (0.70) | DRD4DRD2DRD3ADRA2AADRA2B | |
| SCHEMBL9529266 | 0.76 | DRD2 (0.53) | LMNADRD4DRD2HTR1ASIGMAR1 | |
| SCHEMBL9530260 | 0.75 | SIGMAR1 (0.53) | DRD4DRD2ADRA2AADRA2BADRA2C | |
| SCHEMBL9530838 | 0.72 | L3MBTL1 (0.46) | KDM4ELMNAL3MBTL1DRD4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359790-B1 | 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| US-5084454-A | Tranquilizers and antinausea drugs | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-01-28 | — | — | US | disclosed |