Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR3 | O15455 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531634 | 0.85 | TLR3 (0.47) | TLR3ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL9633267 | 0.81 | TLR3 (0.48) | TLR3ALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL9530858 | 0.77 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2MAPTPOLBHSPB1 | |
| SCHEMBL9632256 | 0.76 | TLR3 (0.46) | TLR3ALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL9531581 | 0.74 | TLR3 (0.41) | TLR3ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL9631049 | 0.72 | TTPA (0.39) | TLR3ALDH1A1MAPTPOLBPKM | |
| SCHEMBL8536557 | 0.70 | TLR3 (0.49) | TLR3ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL9531520 | 0.70 | HIF1A (0.46) | TLR3ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL6958558 | 0.69 | TLR3 (0.44) | TLR3ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL3319434 | 0.69 | KCNE1 (0.44) | TLR3MEN1KMT2AKCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277836-B1 | THIAZOLIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE | Sankyo Company Limited (JP) | 1993-06-02 | — | — | EP | disclosed |
| EP-0251417-B1 | 4-(AROYLAMINO) PIPERIDINEBUTANAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-04-14 | — | — | EP | disclosed |
| US-4873255-A | REDUCE BLOOD GLUCOSE AND BLOOD LIPID LEVELS | SANKYO COMPANY LIMITED (JP) | 1989-10-10 | — | — | US | disclosed |
| EP-0277836-A1 | Thiazolidinone derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1988-08-10 | — | — | EP | disclosed |