Hydrochloric Acid

Hydrochloric Acid

SCHEMBL9538582

O=C(NCC[N+](Cc1ccccc1)(c1ccccc1)c1ccccc1)c1ccccc1.[Cl-]

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 7/20 0.53
NPC1 O15118 6/20 0.53
SMN1; SMN2 Q16637 4/20 0.49
LMNA P02545 2/20 0.49
HDAC2 Q92769 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
POLB P06746 1/20 0.46
GAA P10253 1/20 0.46
KMT2A Q03164 2/20 0.46
MEN1 O00255 1/20 0.46
EPHX2 P34913 1/20 0.45
PRSS1 P07477 1/20 0.45
CTSG P08311 1/20 0.45
CTRB1 P17538 1/20 0.45
CMA1 P23946 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
TAAR1 Q96RJ0 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9539057 0.81 RAB9A (0.54) RAB9ANPC1SMN1; SMN2LMNAHDAC2
SCHEMBL9539316 0.78 NPC1 (0.40) RAB9ANPC1SMN1; SMN2LMNAHDAC2
Hydrochloric Acid SCHEMBL5683129 0.73 RAB9A (0.46) RAB9ANPC1SMN1; SMN2LMNAHDAC2
SCHEMBL3192014 0.73 LMNA (0.77) RAB9ANPC1SMN1; SMN2LMNAHDAC2
SCHEMBL15071554 0.73 LMNA (0.61) RAB9ANPC1SMN1; SMN2LMNAHDAC2
SCHEMBL751214 0.72 HDAC2 (0.80) RAB9ANPC1SMN1; SMN2HDAC2HDAC8
Hydrochloric Acid SCHEMBL5092320 0.71 ALDH1A1 (0.54) SMN1; SMN2KMT2AMEN1TAAR1
Hydrochloric Acid SCHEMBL28193721 0.71 HDAC2 (0.77) RAB9ANPC1SMN1; SMN2HDAC2HDAC8
SCHEMBL9491686 0.69 NPC1 (0.75) RAB9ANPC1SMN1; SMN2LMNAHDAC2
SCHEMBL8779817 0.69 HDAC1 (0.79) RAB9ANPC1SMN1; SMN2LMNAHDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993002399-A1 TONERS AND DEVELOPERS CONTAINING AMIDE-CONTAINING QUATERNARY AMMONIUM SALTS AS CHARGE CONTROL AGENTS EASTMAN KODAK COMPANY (US) 1993-02-04 WO claimed
WO-1993002042-A1 AMIDE-CONTAINING QUATERNARY AMMONIUM SALTS EASTMAN KODAK COMPANY (US) 1993-02-04 WO claimed
US-5162188-A Toners and developers containing amide-containing quaternary ammonium salts as charge control agents EASTMAN KODAK COMPANY (US) 1992-11-10 US claimed
WO-1993002042-A1 AMIDE-CONTAINING QUATERNARY AMMONIUM SALTS EASTMAN KODAK COMPANY (US) 1993-02-04 WO disclosed
WO-1993002399-A1 TONERS AND DEVELOPERS CONTAINING AMIDE-CONTAINING QUATERNARY AMMONIUM SALTS AS CHARGE CONTROL AGENTS EASTMAN KODAK COMPANY (US) 1993-02-04 WO disclosed
US-5162188-A Toners and developers containing amide-containing quaternary ammonium salts as charge control agents EASTMAN KODAK COMPANY (US) 1992-11-10 US disclosed