Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535443 | 0.94 | KMT2A (0.43) | KMT2AMEN1ALDH1A1KDM4EOPRK1 | |
| SCHEMBL9539327 | 0.88 | OPRK1 (0.42) | KMT2AMEN1OPRK1OPRM1SMN1; SMN2 | |
| SCHEMBL9535638 | 0.86 | TACR1 (0.39) | KMT2AMEN1OPRK1SMN1; SMN2TACR1 | |
| SCHEMBL9727534 | 0.84 | ALDH1A1 (0.54) | KMT2AMEN1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL9538257 | 0.84 | KMT2A (0.49) | KMT2AMEN1ALDH1A1KDM4EOPRK1 | |
| SCHEMBL9536562 | 0.81 | OPRK1 (0.44) | KMT2AMEN1ALDH1A1KDM4EOPRK1 | |
| SCHEMBL9535087 | 0.81 | FKBP1A (0.39) | KMT2AMEN1OPRK1OPRM1SMN1; SMN2 | |
| SCHEMBL9536545 | 0.81 | KDM4E (0.38) | KMT2AMEN1ALDH1A1KDM4EOPRK1 | |
| SCHEMBL9538662 | 0.80 | SMN1; SMN2 (0.41) | KMT2AMEN1ALDH1A1OPRK1OPRM1 | |
| SCHEMBL9534208 | 0.80 | KMT2A (0.60) | KMT2AMEN1ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0355599-B1 | 3-ARYL-PYRROLIDINE-2,4-DIONES | BAYER AG (DE) | 1993-05-19 | — | — | EP | disclosed |
| EP-0355599-A1 | 3-Aryl-pyrrolidine-2,4-diones | BAYER AG (DE) | 1990-02-28 | — | — | EP | disclosed |