Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.48 |
| ▸ | DRD2 | P14416 | 7/20 | 0.48 |
| ▸ | HTR2A | P28223 | 7/20 | 0.48 |
| ▸ | DRD3 | P35462 | 7/20 | 0.48 |
| ▸ | DRD1 | P21728 | 3/20 | 0.47 |
| ▸ | DRD5 | P21918 | 3/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.46 |
| ▸ | HRH1 | P35367 | 4/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535966 | 0.88 | MAPT (0.45) | HTR1ADRD2HTR2AHTR2CMEN1 | |
| SCHEMBL10646895 | 0.81 | DRD2 (0.49) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL9538643 | 0.81 | KDM4E (0.45) | HTR1ADRD2HTR2ADRD3SIGMAR1 | |
| SCHEMBL9537865 | 0.78 | SIGMAR1 (0.53) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL9537473 | 0.77 | KDM4E (0.46) | HTR1ADRD2HTR2ADRD1SLC6A3 | |
| SCHEMBL9537905 | 0.76 | SIGMAR1 (0.47) | HTR1ADRD2HTR2ASIGMAR1MEN1 | |
| SCHEMBL9535969 | 0.76 | AR (0.48) | HTR1ADRD2HTR2ADRD3HTR2C | |
| SCHEMBL9536766 | 0.76 | ALDH1A1 (0.42) | DRD2DRD3HRH1SIGMAR1HRH2 | |
| SCHEMBL9536717 | 0.71 | HTR1A (0.38) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL8011318 | 0.70 | DRD2 (0.69) | HTR1ADRD2HTR2ADRD3DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254623-B1 | AMINOALKYLTHIO TRIAZOLOPYRIDINE OR TRIAZOLOQUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM, PARTICULARLY USEFUL AS ANTALGICS | LABORATOIRES UPSA (FR) | 1993-06-09 | — | — | EP | disclosed |