Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.50 |
| ▸ | DRD3 | P35462 | 4/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9559709 | 0.90 | DRD2 (0.55) | DRD2DRD3DRD4ADORA2BHTR4 | |
| SCHEMBL9559661 | 0.86 | TP53 (0.51) | DRD2DRD3DRD4ADORA2BHTR4 | |
| SCHEMBL9559704 | 0.86 | THRB (0.57) | DRD2DRD3ADORA2BHTR4TP53 | |
| SCHEMBL9559698 | 0.82 | DRD2 (0.62) | DRD2DRD3TP53CACNA1GMEN1 | |
| SCHEMBL9228971 | 0.78 | DRD3 (0.55) | DRD2DRD3DRD4TP53MEN1 | |
| SCHEMBL5654727 | 0.77 | ADRA1D (0.62) | DRD2DRD3DRD4ADORA2BHTR4 | |
| SCHEMBL11168269 | 0.76 | DRD2 (0.67) | DRD2DRD3DRD4CACNA1GMEN1 | |
| SCHEMBL9559731 | 0.76 | THRB (0.59) | DRD2DRD3DRD4ADORA2BHTR4 | |
| SCHEMBL9559630 | 0.75 | TP53 (0.56) | DRD2DRD4ADORA2BHTR4TP53 | |
| SCHEMBL9229836 | 0.73 | MEN1 (0.52) | DRD2DRD3MEN1KMT2ASLC29A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544765-A1 | PIPERAZINYL DERIVATIVES. | NOVO NORDISK AS (DK) | 1993-06-09 | — | — | EP | claimed |
| WO-1992003426-A1 | PIPERAZINYL DERIVATIVES | NOVO NORDISK A/S (DK) | 1992-03-05 | — | — | WO | claimed |
| US-5246935-A | Cardiovascular and gastrointestinal | NOVO NORDISK A/S (DK) | 1993-09-21 | — | — | US | disclosed |
| EP-0544765-A1 | PIPERAZINYL DERIVATIVES. | NOVO NORDISK AS (DK) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992003426-A1 | PIPERAZINYL DERIVATIVES | NOVO NORDISK A/S (DK) | 1992-03-05 | — | — | WO | disclosed |