SCHEMBL9566058

SCHEMBL9566058

CON(C)C(=O)NN=C(c1ccc(F)cc1)c1ccc(OS(=O)(=O)C(F)(F)F)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCR2 P25025 2/20 0.37
RAB9A P51151 3/20 0.37
MAPT P10636 4/20 0.34
ALDH1A1 P00352 3/20 0.34
HTT P42858 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
CXCR1 P25024 1/20 0.34
TAS2R14 Q9NYV8 1/20 0.34
KDM4E B2RXH2 1/20 0.34
LMNA P02545 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
CTSL P07711 3/20 0.34
CTSK P43235 1/20 0.34
CA1 P00915 2/20 0.33
CA2 P00918 2/20 0.33
CA9 Q16790 2/20 0.33
CA4 P22748 1/20 0.33
CA12 O43570 1/20 0.33
BCL2L1 Q07817 1/20 0.33
MCL1 Q07820 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9416661 0.90 RAB9A (0.42) CXCR2RAB9AMAPTALDH1A1KDM4E
SCHEMBL9566152 0.80 PAX8 (0.36) CXCR2RAB9AALDH1A1CXCR1TAS2R14
SCHEMBL8538819 0.80 CXCR2 (0.41) CXCR2MAPTALDH1A1HTTSMN1; SMN2
SCHEMBL9566010 0.78 ALDH1A1 (0.35) CXCR2RAB9AALDH1A1SMN1; SMN2CTSL
SCHEMBL9566069 0.77 RAB9A (0.45) RAB9AMAPTALDH1A1HTTSMN1; SMN2
SCHEMBL9566024 0.76 MEN1 (0.35) CXCR2MAPTALDH1A1LMNACA1
SCHEMBL21358357 0.75 MLYCD (0.56) CXCR2RAB9AMAPTALDH1A1HTT
SCHEMBL9079609 0.73 MEN1 (0.42) CXCR2MAPTALDH1A1SMN1; SMN2CXCR1
SCHEMBL10973313 0.73 MEN1 (0.42) CXCR2MAPTALDH1A1SMN1; SMN2CXCR1
SCHEMBL9234669 0.72 STS (0.53) CXCR2MAPTALDH1A1SMN1; SMN2CXCR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0566534-A1 Derivatives of benzophenone CIBA-GEIGY AG (CH) 1993-10-20 EP claimed
EP-0566534-A1 Derivatives of benzophenone CIBA-GEIGY AG (CH) 1993-10-20 EP disclosed