Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 10/20 | 0.37 |
| ▸ | CTSL | P07711 | 5/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9568074 | 0.87 | CTSS (0.41) | CTSSCTSLADAMTS4ADAMTS5NPC1 | |
| SCHEMBL9568122 | 0.86 | CTSS (0.43) | CTSSCTSLADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL9568197 | 0.83 | ITGB3 (0.45) | CTSSCTSLADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL8886008 | 0.71 | MAPT (0.49) | CTSSCTSLALDH1A1NPC1RAB9A | |
| SCHEMBL9568108 | 0.70 | POLB (0.38) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL2247378 | 0.68 | ADAMTS5 (0.59) | CTSSCTSLADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL2247765 | 0.68 | ADAMTS5 (0.59) | CTSSCTSLADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL9252697 | 0.66 | HDAC6 (0.42) | CTSSCTSLCTSKSMN1; SMN2KMT2A | |
| SCHEMBL7331480 | 0.65 | ITGB3 (0.42) | CTSSCTSLALDH1A1NPC1RAB9A | |
| SCHEMBL8408125 | 0.65 | CTSL (0.41) | CTSSCTSLALDH1A1CTSKSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574808-A1 | Amidine-biphenyl derivatives, process for their production & medical preparation containing them | Dr. Karl Thomae GmbH (DE) | 1993-12-22 | — | — | EP | disclosed |