Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.48 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8985248 | 1.00 | KDM4E (0.57) | KDM4EACHEBACE1SMN1; SMN2LMNA | |
| SCHEMBL8985153 | 0.94 | KDM4E (0.63) | KDM4EACHEBACE1SMN1; SMN2LMNA | |
| SCHEMBL8985169 | 0.78 | KDM4E (0.57) | KDM4EACHEBACE1SMN1; SMN2LMNA | |
| SCHEMBL8985443 | 0.75 | KDM4E (0.59) | KDM4EACHEBACE1SMN1; SMN2LMNA | |
| Fumaric Acid SCHEMBL7354752 | 0.74 | KDM4E (0.48) | KDM4EACHEBACE1SMN1; SMN2LMNA | |
| Fumaric Acid SCHEMBL7354754 | 0.74 | KDM4E (0.48) | KDM4EACHEBACE1SMN1; SMN2LMNA | |
| Fumaric Acid SCHEMBL7330535 | 0.73 | ADRA1A (0.50) | KDM4EACHEBACE1SMN1; SMN2LMNA | |
| Fumaric Acid SCHEMBL7330519 | 0.73 | SMN1; SMN2 (0.49) | KDM4EACHEBACE1SMN1; SMN2LMNA | |
| SCHEMBL24493549 | 0.71 | KDM4E (0.47) | KDM4ESMN1; SMN2LMNAKMT2AALDH1A1 | |
| SCHEMBL27339399 | 0.71 | SMN1; SMN2 (0.85) | KDM4EACHEBACE1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532754-A1 | TETRAHYDROIMIDAZOPYRIDINE DERIVATIVE OR ITS SALT | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1993-03-24 | — | — | EP | disclosed |