Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2685247 | 0.77 | APP (0.39) | MAPTLMNAAKR1C2AKR1C1ALDH1A1 | |
| SCHEMBL22300264 | 0.72 | GABRA1 (0.42) | MAPTLMNAALDH1A1HTTCYP3A4 | |
| SCHEMBL9578277 | 0.71 | ALDH1A1 (0.38) | MAPTLMNAALDH1A1HTTCYP3A4 | |
| SCHEMBL9578385 | 0.71 | LMNA (0.48) | MAPTLMNAAKR1C2AKR1C1ALDH1A1 | |
| SCHEMBL2683928 | 0.70 | CACNA2D1 (0.40) | MAPTALDH1A1HTTTSHRIDO1 | |
| SCHEMBL2684286 | 0.70 | ACP3 (0.45) | MAPTLMNAALDH1A1HTTTSHR | |
| SCHEMBL6721147 | 0.69 | AKR1C2 (0.71) | MAPTLMNAAKR1C2AKR1C1ALDH1A1 | |
| SCHEMBL9667703 | 0.67 | APP (0.39) | MAPTLMNAALDH1A1HTTCYP3A4 | |
| SCHEMBL2686082 | 0.67 | IDO1 (0.44) | LMNAALDH1A1CYP3A4IDO1GAA | |
| SCHEMBL9670146 | 0.67 | CES2 (0.40) | MAPTLMNAALDH1A1CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0401517-B1 | Substituted 2-alkynylphenols with anti-inflammatory action, a process for their preparation and pharmaceutical compositions thereof | CORVI CAMILLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| EP-0401517-A1 | Substituted 2-alkynylphenols with anti-inflammatory action, a process for their preparation and pharmaceutical compositions thereof | CAMILLO CORVI S.p.A. (IT) | 1990-12-12 | — | — | EP | disclosed |