Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.47 |
| ▸ | GRM6 | O15303 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9586819 | 0.90 | GRM6 (0.54) | CDC7DBF4GRM6MAPTNPC1 | |
| SCHEMBL9586899 | 0.82 | ILK (0.43) | MAPTALDH1A1KDM4EMAPK1L3MBTL1 | |
| SCHEMBL9588826 | 0.80 | MAPT (0.45) | CDC7DBF4MAPTNPC1RAB9A | |
| SCHEMBL9587799 | 0.80 | MAPT (0.53) | CDC7DBF4MAPTNPC1RAB9A | |
| SCHEMBL9585511 | 0.80 | KDM4E (0.55) | KDM4EMAPK1TSHR | |
| SCHEMBL9586392 | 0.80 | JAK2 (0.46) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL27768167 | 0.80 | ALDH1A1 (0.49) | GRM6MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL9587231 | 0.79 | KDM4E (0.49) | MAPTRAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL9585878 | 0.78 | TRPM8 (0.53) | MAPTALDH1A1KDM4EL3MBTL1CYP2C9 | |
| SCHEMBL13398594 | 0.77 | GABRG2 (0.43) | MAPTNPC1RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204482-A | Ethylenediamine monoamide heteroaryl derivatives | HOFFMAN-LAROCHE INC. (US) | 1993-04-20 | — | — | US | disclosed |
| US-5011849-A | Monoamine oxidase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1991-04-30 | — | — | US | disclosed |