SCHEMBL959185

SCHEMBL959185

C=CCOC(=O)C=Cc1ccc(O)c(OC)c1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.74
APP P05067 3/20 0.73
EPHX2 P34913 1/20 0.68
MET P08581 8/20 0.66
CA12 O43570 5/20 0.66
CA4 P22748 5/20 0.66
CA6 P23280 5/20 0.66
CA5A P35218 5/20 0.66
CA7 P43166 5/20 0.66
CA9 Q16790 5/20 0.66
CA14 Q9ULX7 5/20 0.66
CA5B Q9Y2D0 5/20 0.66
CYP2D6 P10635 3/20 0.64
CYP2C9 P11712 2/20 0.64
TSHR P16473 2/20 0.64
HSD17B10 Q99714 2/20 0.64
CYP1A2 P05177 2/20 0.64
ALOX5 P09917 2/20 0.64
NFKB1 P19838 2/20 0.64
HSD11B1 P28845 2/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14232132 1.00 MAOB (0.74) MAOBAPPEPHX2METCA12
SCHEMBL9044207 0.90 APP (0.73) MAOBAPPEPHX2MAPTMAOA
SCHEMBL9044203 0.90 APP (0.73) MAOBAPPEPHX2MAPTMAOA
SCHEMBL23310889 0.89 APP (0.77) MAOBAPPEPHX2METCA12
SCHEMBL28519058 0.88 FDPS (0.65) MAOBAPPEPHX2METHSD17B10
SCHEMBL23869888 0.88 APP (0.60) MAOBAPPEPHX2METCA12
SCHEMBL434930 0.88 MAOB (0.76) MAOBAPPEPHX2METCA12
SCHEMBL10054940 0.88 MAOB (0.76) MAOBAPPEPHX2METCA12
SCHEMBL27520787 0.88 MAOB (0.76) MAOBAPPEPHX2METCA12
Curcumin SCHEMBL1665539 0.86 APP (0.76) MAOBAPPCA12CA4CA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112043716-A Pharmaceutical composition with neuroprotective activity, extraction method and application thereof 深圳红景堂生物医药科技有限公司 2020-12-08 CN claimed
CN-116179509-A Method for synthesizing phenyl acrylate by feruloyl esterase catalysis 广西大学 2023-05-30 CN disclosed
CN-106692961-B Arginase composition, arginase activator and application thereof 长春市福迪奥美科技有限公司 2020-12-11 CN disclosed
CN-112043716-A Pharmaceutical composition with neuroprotective activity, extraction method and application thereof 深圳红景堂生物医药科技有限公司 2020-12-08 CN disclosed
CN-112043716-A Pharmaceutical composition with neuroprotective activity, extraction method and application thereof 深圳红景堂生物医药科技有限公司 2020-12-08 CN disclosed
CN-110833541-A Preparation method of ferulic acid butyl ester and functional application of ferulic acid butyl ester in treating or preventing Alzheimer's disease 浙江工商大学 2020-02-25 CN disclosed
US-9939555-B2 Cinnamic acid derivative, polymer thereof, and liquid crystal alignment layer comprising cured product thereof DIC CORPORATION (JP) 2018-04-10 US disclosed
CN-107050100-A Red stilbene Chinese medicine is taken after being infused in hot water or decoction medicine materical crude slice 江苏苏轩堂药业有限公司 2017-08-18 CN disclosed
US-9684206-B2 Copolymer, and liquid crystal alignment layer including cured product thereof DIC CORPORATION (JP) 2017-06-20 US disclosed
EP-2727947-B1 COPOLYMER, AND LIQUID CRYSTAL ALIGNMENT LAYER COMPRISING HARDENED PRODUCT THEREOF DAINIPPON INK & CHEMICALS (JP) 2017-03-15 EP disclosed
US-20140121345-A1 CINNAMIC ACID DERIVATIVE, POLYMER THEREOF, AND LIQUID CRYSTAL ALIGNMENT LAYER COMPRISING CURED PRODUCT THEREOF DIC CORPORATION (JP) 2014-05-01 US disclosed
CN-103619803-A Cinnamic acid derivative, polymer thereof, and liquid crystal alignment layer comprising cured product thereof DAINIPPON INK & CHEMICALS 2014-03-05 CN disclosed
US-20110002968-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION CONTAINING AN ORCHID EXTRACT, AND COSMETIC CARE METHOD USING SAID COMPOSITION LVMH RECHERCHE (FR) 2011-01-06 US disclosed
US-20100291151-A1 1-METHYLPYRAZOLE MODULATORS OF SUBSTANCE P, CALCITONIN GENE-RELATED PEPTIDE, ADRENERGIC RECEPTOR, AND/OR 5-HT RECEPTOR AUSPEX PHARMACEUTICALS, INC. (US) 2010-11-18 US disclosed
JP-2005015453-A COSMETIC COMPOSITION CONTAINING ISOSTEARYL FERULATE MATSUMOTO TRADING CO LTD 2005-01-20 JP disclosed
US-6436991-B1 FERULATE COMPOUNDS SABINSA CORPORATION 2002-08-20 US disclosed
US-20020061929-A1 Ferulate compounds SAMI LABS LIMITED (IN) 2002-05-23 US disclosed
JP-2002030039-A METHOD FOR PRODUCING CARCINOGENESIS PREVENTING SUBSTANCE WAKAYAMA PREFECTURE 2002-01-29 JP disclosed
WO-2001090064-A2 COMPOSITION AND METHOD CONTAINING PRODUCTS EXTRACTED FROM COMMIPHORA Sp. FOR PREVENTION AND TREATMENT OF ABNORMAL CELL GROWTH AND PROLIFERATION IN INFLAMMATION, NEOPLASIA AND CARDIOVASCULAR DISEASE SABINSA CORPORATION (US) 2001-11-29 WO disclosed
EP-0742012-A2 Pharmaceutical composition containing substance inhibiting HSP47 production Kureha Chemical Industry Co., Ltd. (JP) 1996-11-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100291151-A1 1-METHYLPYRAZOLE MODULATORS OF SUBSTANCE P, CALCITONIN GENE-RELATED PEPTIDE, ADRENERGIC RECEPTOR, AND/OR 5-HT RECEPTOR TACR1, HTR3A, HTR3C MAOB 287/4885APP 599/4885EPHX2 1615/4885
US-20020061929-A1 Ferulate compounds FER, FIBP, VHL MAOB 1178/4885APP 4566/4885EPHX2 3633/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.