Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602248 | 0.87 | MEN1 (0.43) | SMN1; SMN2KMT2ATSHRNPSR1MEN1 | |
| SCHEMBL9602370 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2ATSHRNPSR1MEN1 | |
| SCHEMBL7272509 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2KMT2ATSHRNPSR1MEN1 | |
| SCHEMBL9601571 | 0.72 | MEN1 (0.51) | KMT2AMEN1HTR4CYP2D6CYP2C19 | |
| SCHEMBL9601933 | 0.72 | HTR3A (0.45) | KMT2AMEN1NOTUM | |
| SCHEMBL9602854 | 0.71 | CHRNA7 (0.50) | — | |
| SCHEMBL27822313 | 0.71 | ALDH1A1 (0.47) | SMN1; SMN2KMT2ATSHRMEN1POLB | |
| SCHEMBL9602598 | 0.70 | DRD2 (0.46) | SMN1; SMN2POLBALDH1A1NPC1RAB9A | |
| SCHEMBL27761216 | 0.69 | NOTUM (0.57) | SMN1; SMN2KMT2ATSHRMEN1POLB | |
| SCHEMBL7266518 | 0.68 | SMN1; SMN2 (0.67) | SMN1; SMN2KMT2ATSHRNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0247266-B1 | INDOLE DERIVATIVES HAVING AN AZABICYCLIC SIDE CHAIN, PROCESS FOR THEIR PREPARATION, INTERMEDIATES, AND PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1993-03-10 | — | — | EP | claimed |