Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 3/20 | 0.48 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.41 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.41 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.41 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9601571 | 0.86 | MEN1 (0.51) | HTR4NOTUMCHRM1 | |
| SCHEMBL9601933 | 0.86 | HTR3A (0.45) | HTR3ANOTUMCHRM1 | |
| SCHEMBL7265532 | 0.84 | NOTUM (0.56) | HTR3AHTR4NOTUMALDH1A1TUBB4A | |
| SCHEMBL9602598 | 0.83 | DRD2 (0.46) | ALDH1A1DPP4 | |
| SCHEMBL9602248 | 0.83 | MEN1 (0.43) | HTR3AHTR4ALDH1A1HSD17B10 | |
| SCHEMBL9602370 | 0.79 | SMN1; SMN2 (0.48) | HTR3A | |
| SCHEMBL9602198 | 0.77 | DRD2 (0.46) | ALDH1A1 | |
| SCHEMBL9601408 | 0.72 | SMN1; SMN2 (0.48) | HTR4NOTUMALDH1A1 | |
| SCHEMBL10537786 | 0.70 | MAPT (0.67) | HTR3AHTR4ALDH1A1 | |
| SCHEMBL16018991 | 0.69 | PKM (0.60) | HTR3AHTR4ALDH1A1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0247266-B1 | INDOLE DERIVATIVES HAVING AN AZABICYCLIC SIDE CHAIN, PROCESS FOR THEIR PREPARATION, INTERMEDIATES, AND PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1993-03-10 | — | — | EP | claimed |