Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | OGG1 | O15527 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 4/20 | 0.35 |
| ▸ | PKLR | P30613 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1355977 | 0.94 | SMN1; SMN2 (0.36) | SMN1; SMN2HSD17B10HTR6OGG1PKM | |
| Fumaric Acid SCHEMBL1355982 | 0.94 | SMN1; SMN2 (0.36) | SMN1; SMN2HSD17B10HTR6OGG1PKM | |
| SCHEMBL1358382 | 0.83 | RAPGEF4 (0.45) | SMN1; SMN2OGG1KMT2ALMNAHTT | |
| SCHEMBL1357890 | 0.81 | NR1H2 (0.48) | SMN1; SMN2HTR6PKMMEN1KMT2A | |
| SCHEMBL9611280 | 0.78 | RAB9A (0.42) | SMN1; SMN2PKMKMT2ALMNATSHR | |
| SCHEMBL12136107 | 0.77 | MAPT (0.41) | HTR6KMT2ALMNATSHRHTT | |
| SCHEMBL1357268 | 0.77 | HTR6 (0.44) | HTR6OGG1MEN1KMT2ALMNA | |
| SCHEMBL1357717 | 0.75 | SMN1; SMN2 (0.40) | SMN1; SMN2HSD17B10HTR6OGG1PKM | |
| SCHEMBL9611273 | 0.75 | ADRB2 (0.41) | SMN1; SMN2HSD17B10OGG1LMNATSHR | |
| Fumaric Acid SCHEMBL3696438 | 0.74 | HTR6 (0.39) | SMN1; SMN2HTR6PKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2005957-B1 | ACID SECRETION INHIBITOR | TAKEDA PHARMACEUTICAL (JP) | 2012-05-30 | — | — | EP | disclosed |
| US-20110288040-A1 | ARYL- OR HETEROARYL-SULFONYL COMPOUNDS AS ACID SECRETION INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | US | disclosed |
| US-20110288040-A1 | ARYL- OR HETEROARYL-SULFONYL COMPOUNDS AS ACID SECRETION INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | US | disclosed |
| US-7994205-B2 | Aryl-or heteroaryl-sulfonyl compounds as acid secretion inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-08-09 | — | — | US | disclosed |
| US-7994205-B2 | Aryl-or heteroaryl-sulfonyl compounds as acid secretion inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-08-09 | — | — | US | disclosed |
| US-20090118335-A1 | Acid Secretion Inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-07 | — | — | US | disclosed |
| US-20090118335-A1 | Acid Secretion Inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-07 | — | — | US | disclosed |
| EP-2005957-A1 | ACID SECRETION INHIBITOR | Takeda Pharmaceutical Company Limited (JP) | 2008-12-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118335-A1 | Acid Secretion Inhibitor | ATP6AP1, HRH2, ATP6V1G1 | SMN1; SMN2 3892/4885HSD17B10 459/4885HTR6 2825/4885 |
| US-20110288040-A1 | ARYL- OR HETEROARYL-SULFONYL COMPOUNDS AS ACID SECRETION INHIBITORS | GHSR, GIPR, HRH2 | SMN1; SMN2 3639/4885HSD17B10 612/4885HTR6 1927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.