Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1357693 | 0.94 | RAB9A (0.39) | RAB9AHTTNPC1SMN1; SMN2LMNA | |
| Fumaric Acid SCHEMBL1357695 | 0.94 | RAB9A (0.39) | RAB9AHTTNPC1SMN1; SMN2LMNA | |
| SCHEMBL13801543 | 0.85 | RAB9A (0.40) | RAB9AHTTNPC1SMN1; SMN2LMNA | |
| SCHEMBL13999993 | 0.84 | HTT (0.43) | RAB9AHTTSMN1; SMN2LMNATSHR | |
| Fumaric Acid SCHEMBL3703509 | 0.82 | RAB9A (0.36) | RAB9AHTTNPC1SMN1; SMN2LMNA | |
| Fumaric Acid SCHEMBL3703504 | 0.82 | RAB9A (0.36) | RAB9AHTTNPC1SMN1; SMN2LMNA | |
| SCHEMBL9611273 | 0.81 | ADRB2 (0.41) | HTTSMN1; SMN2LMNATSHR | |
| SCHEMBL1357890 | 0.80 | NR1H2 (0.48) | HTTSMN1; SMN2LMNATSHRPKM | |
| SCHEMBL1358382 | 0.78 | RAPGEF4 (0.45) | HTTSMN1; SMN2LMNAKMT2AL3MBTL1 | |
| SCHEMBL9611258 | 0.78 | SMN1; SMN2 (0.39) | HTTSMN1; SMN2LMNATSHRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2005957-B1 | ACID SECRETION INHIBITOR | TAKEDA PHARMACEUTICAL (JP) | 2012-05-30 | — | — | EP | disclosed |
| US-20110288040-A1 | ARYL- OR HETEROARYL-SULFONYL COMPOUNDS AS ACID SECRETION INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | US | disclosed |
| US-20110288040-A1 | ARYL- OR HETEROARYL-SULFONYL COMPOUNDS AS ACID SECRETION INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | US | disclosed |
| US-7994205-B2 | Aryl-or heteroaryl-sulfonyl compounds as acid secretion inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-08-09 | — | — | US | disclosed |
| US-7994205-B2 | Aryl-or heteroaryl-sulfonyl compounds as acid secretion inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-08-09 | — | — | US | disclosed |
| US-20090118335-A1 | Acid Secretion Inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-07 | — | — | US | disclosed |
| US-20090118335-A1 | Acid Secretion Inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118335-A1 | Acid Secretion Inhibitor | ATP6AP1, HRH2, ATP6V1G1 | RAB9A 740/4885HTT 4252/4885NPC1 595/4885 |
| US-20110288040-A1 | ARYL- OR HETEROARYL-SULFONYL COMPOUNDS AS ACID SECRETION INHIBITORS | GHSR, GIPR, HRH2 | RAB9A 1149/4885HTT 3342/4885NPC1 350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.