Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 4/20 | 0.51 |
| ▸ | MAOB | P27338 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9615095 | 0.87 | PTGDR2 (0.62) | PTGDR2HDAC6ENPP2HDAC10 | |
| SCHEMBL9615138 | 0.81 | HDAC6 (0.64) | PTGDR2HDAC6HDAC1HDAC10 | |
| SCHEMBL11755903 | 0.79 | ALDH1A1 (0.52) | PTGDR2HDAC6HDAC1MAOAMAOB | |
| SCHEMBL12938917 | 0.77 | HDAC6 (0.78) | HDAC6HDAC1ENPP2MAOAMAOB | |
| SCHEMBL17517481 | 0.76 | MAOA (0.79) | HDAC6HDAC1MAOAMAOBKDM4E | |
| SCHEMBL17486942 | 0.76 | ENPP2 (0.54) | PTGDR2ENPP2 | |
| SCHEMBL5373029 | 0.74 | ENPP2 (0.53) | PTGDR2HDAC6HDAC1ENPP2KDM4E | |
| SCHEMBL28810472 | 0.73 | HDAC6 (0.71) | PTGDR2HDAC6HDAC1ENPP2HDAC10 | |
| SCHEMBL1002965 | 0.73 | HDAC6 (0.71) | HDAC6HDAC1ENPP2MAOAMAOB | |
| SCHEMBL10122059 | 0.73 | CNR2 (0.51) | PTGDR2HDAC6HDAC1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5169852-A | Anorexigenic agents | NEUREX CORPORATION (US) | 1992-12-08 | — | — | US | disclosed |
| EP-0520987-A4 | METHOD OF SUPPRESSING APPETITE BY ADMINISTRATION OF TETRAHYDRO--g(b)-CARBOLINE DERIVATIVES. | NEUREX CORP (US) | 1992-05-13 | — | — | EP | disclosed |
| US-4978669-A | ALTERING MACRONUTRIENT PREFERENCE | NEUREX CORPORATION (US) | 1990-12-18 | — | — | US | disclosed |