Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 4/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5339410 | 0.76 | MTNR1A (0.52) | BRD4CREBBPDRD2SLC6A4 | |
| SCHEMBL9626819 | 0.73 | PKM (0.39) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9095936 | 0.70 | DRD2 (0.35) | BRD4CREBBPNPC1MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL9095687 | 0.69 | DRD2 (0.35) | BRD4CREBBPNPC1MAPK13MAPK12 | |
| SCHEMBL9626626 | 0.66 | PDE3B (0.33) | — | |
| SCHEMBL9626749 | 0.65 | PDE4D (0.38) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9094190 | 0.64 | BRD4 (0.33) | BRD4CREBBPDRD2ADRA1DSLC6A4 | |
| SCHEMBL5783955 | 0.64 | MAPT (0.34) | CHEK1 | |
| SCHEMBL8806234 | 0.63 | HSP90AA1 (0.37) | DRD2SLC6A4LMNA | |
| SCHEMBL8805917 | 0.63 | DRD2 (0.37) | DRD2ADRA1DSLC6A4ADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5093339-A | Anticoagulant, hypotensive, antiangina, antiasthma, antiulcer, anti-platelet activating factor | KODAMA KABUSHIKI KAISHA (JP) | 1992-03-03 | — | — | US | disclosed |
| EP-0355689-A2 | Pyrano [f] quinoline derivatives and pharmaceutical compositions containing the same | KODAMA KABUSHIKI KAISHA (JP) | 1990-02-28 | — | — | EP | disclosed |